Publications
66. Beyond N-alkylation: Synthesis, structure and function of N-amino peptides
Angera IJ, Wright MM, Del Valle JR.
Acc. Chem. Res. (2024) ASAP. Link
Angera IJ, Wright MM, Del Valle JR.
Acc. Chem. Res. (2024) ASAP. Link
65. Structure-based design of seed-competent proteomimetic macrocycles derived from 4R tauopathic folds
Angera IJ, Xu X, Rajewski BH, Hallinan GI, Ghetti B, Vidal R, Jiang W, Del Valle JR.
Submitted; available at ChemRxiv (2024). Link
64. Stabilizing pseudouridimycin: Synthesis, RNA-polymerase inhibitory activity, and antibacterial activity of dipeptide-
modified analogues
Anwar AF, Cain CF, Garza MJ, Degen D, Ebright RH, Del Valle JR.
ChemMedChem (2024) 19, e202300474. Link
63. β-Bracelets: Macrocyclic cross-β epitope mimics based on a tau conformational strain
Rajewski BH, Makwana KM, Angera IJ, Geremia DK, Zepeda AR, Hallinan GI, Vidal R, Ghetti B, Serrano AL, Del Valle JR.
J. Am. Chem. Soc. (2023) 141, 23131. Link
62. Blocking tau transmission with biomimetic graphene nanoparticles
Zhu R, Makwana KM, Zhang Y, Rajewski BH, Del Valle JR, Wang Y.
J. Mater. Chem. B (2023) 11, 7378. Link
61. N-Aminoglycine and its derivatives stabilize PPII secondary structure
Rajewski BH, Wright MM, Gerrein TA, Del Valle JR.
Org. Lett. (2023) 25, 4366. Link
Rajewski BH, Wright MM, Gerrein TA, Del Valle JR.
Org. Lett. (2023) 25, 4366. Link
60. Total synthesis of pargamicin A
Elbatrawi YM, Gerrein TA, Anwar A, Makwana K, Degen D, Ebright RH, Del Valle JR.
Org. Lett. (2022) 24, 9285 Link
59. Late-stage sidechain-to-backbone macrocyclization of N-amino peptides
Rathman BM, Del Valle JR.
Org. Lett. (2022) 24, 1536. Link
58. Total synthesis and chemical stability of pseudouridimycin
Cain CF, Scott AM, Del Valle JR.
Chem. Commun. (2022) 58, 2351. Link (post-production correction: Link)
57. An IRE-1-targeting caged prodrug with ER stress-inducing and XBP-1s-inhibiting activities for cancer therapy.
Shao A, Xu Q, Kang C, Cain CF, Tang C, Del Valle JR, Hu C.
Mol. Pharm. (2022) 19, 1059. Link
56. N-amination converts amyloidogenic tau peptides into soluble antagonists of cellular seeding
Makwana K, Sarnowski MP, Miao J, Lin, Y, Del Valle JR.
ACS Chem. Neuro. (2021) 12, 3928. Link
55. Diastereoselective synthesis of (3R,5R)-Ɣ-hydroxypiperazic acid
Gerrein T, Elbatrawi YM, Del Valle JR.
Synlett (2021) 32, 1747. Link
54. Synthesis and conformation of backbone N-aminated peptides.
Rathman BM, Rowe JL, Del Valle JR.
Methods in Enzymology (2021) 656, 271 . Link
53. STING regulates BCR signaling in normal and malignant B cells
Tang C, Lee, AC, Chang S, Xu Q, Shao A, Lo Y, Spalek WT, Pinilla-Ibarz JA, Del Valle JR, Hu, CA.
Cell. Mol. Immunol. (2021) 18, 1016. Link
52. Development of tumor-targeting IRE-1 inhibitors for B cell cancer therapy
Shao A, Xu Q, Spalek WT, Cain CF, Kang C, Tang C, Del Valle JR, Hu C.
Mol. Cancer Ther. (2020) 19, 2432. Link
Shao A, Xu Q, Spalek WT, Cain CF, Kang C, Tang C, Del Valle JR, Hu C.
Mol. Cancer Ther. (2020) 19, 2432. Link
51. Synthesis and biological evaluation of backbone-aminated analogues of gramicidin S
Rathman BM, Adams JL, Shaw LN, Del Valle JR*.
Bioorg. Med. Chem. Lett. (2020) 30, 127283. Link
50. N-Hydroxy peptides: Synthesis and β-sheet propensity
Sarnowski MP and Del Valle JR*.
Org. Biomol. Chem. (2020) 18, 3690. Link
Sarnowski MP and Del Valle JR*.
Org. Biomol. Chem. (2020) 18, 3690. Link
49. N-Amino peptide scanning reveals inhibitors of Aβ42 aggregation
Tillett KC and Del Valle JR*.
RSC Adv. (2020), 10, 14331. Link
48. δ-Azaproline and its oxidized variants
Elbatrawi YM, Pedretty KP, Giddings N, Woodcock HL, Del Valle JR*.
J. Org. Chem. (2020), 85, 4207. Link
47. Synthesis of enantiopure ε-oxapipecolic acid
Howard EH, Cain CF, KangC, Del Valle JR*. J.
Org. Chem. (2020) 85, 1680. Link
46. Structural tailoring of a novel fluorescent IRE-1 RNase inhibitor to precisely control its activity
Shao, A, Kang C, Tang C, Cain CF, Xu Q, Phoumyvong C, Del Valle JR*, Hu C*
J. Med. Chem. (2019) 62, 5404. Link
45. Synthetic studies toward eleganine A
Cain CF, Howard EH, Goodwin JA, Del Valle JR*,
Arkivoc (2019) 80. Link
44. Adaptive ER stress signaling via IRE1α/XBP1 preserves self-renewal of hematopoietic and pre-leukemic stem cells
Liu L, Zhao M, Jin X, Ney G, Yang K, Peng F, Cao J, Iwawaki T, Del Valle JR, Chen X, Li Q*
Nat. Cell Biol. (2019), 21, 328. Link
43. Inhibition of human dendritic cell ER stress response reduces T cell alloreactivity yet spares donor anti-tumor
immunity
Betts BC*, Locke FL, Sagatys EM, Pidala J, Walton K, Menges M, Reff J, Saha A, Djeu JY, Kiluk JV, Lee MC, Kim J, Kang CW,
Tang CA, Frieling J, Lynch CC, List A, Rodriguez PC, Blazar BR, Conejo-Garcia JR, Del Valle JR, Hu CA, Anasetti C.
Front. Immunol. (2018) 9, 2887. Link
42. Total synthesis of L-156,373 and an oxoPiz analogue via a submonomer approach
Elbatrawi YM, Kang C, Del Valle JR*
Org. Lett. (2018), 20, 2707. Link
Liu L, Zhao M, Jin X, Ney G, Yang K, Peng F, Cao J, Iwawaki T, Del Valle JR, Chen X, Li Q*
Nat. Cell Biol. (2019), 21, 328. Link
43. Inhibition of human dendritic cell ER stress response reduces T cell alloreactivity yet spares donor anti-tumor
immunity
Betts BC*, Locke FL, Sagatys EM, Pidala J, Walton K, Menges M, Reff J, Saha A, Djeu JY, Kiluk JV, Lee MC, Kim J, Kang CW,
Tang CA, Frieling J, Lynch CC, List A, Rodriguez PC, Blazar BR, Conejo-Garcia JR, Del Valle JR, Hu CA, Anasetti C.
Front. Immunol. (2018) 9, 2887. Link
42. Total synthesis of L-156,373 and an oxoPiz analogue via a submonomer approach
Elbatrawi YM, Kang C, Del Valle JR*
Org. Lett. (2018), 20, 2707. Link
41. Secretory IgM exacerbates tumor progression by inducing accumulations of MDSCs in mice
Tang CA, Chang S, Hashimoto A, Chen Y, Kang C, Mato AR, Del Valle JR, Gabrilovich D, Hu CA*
Cancer Immun. Res. (2018), 6, 696. Link
40. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization
Tang CA, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CA*
J. Cell Biol. (2018) 217, 1739. Link
39. IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Xie, H, Tang CA, Song JH, Mancuso A, Del Valle JR, Cao J, Xiang Y, Dand CV, Sanchez DJ, Keith B, Hu CA, Simon MC*
J. Clin. Inv. (2018), 128, 1300. Link
Tang CA, Chang S, Hashimoto A, Chen Y, Kang C, Mato AR, Del Valle JR, Gabrilovich D, Hu CA*
Cancer Immun. Res. (2018), 6, 696. Link
40. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization
Tang CA, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CA*
J. Cell Biol. (2018) 217, 1739. Link
39. IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Xie, H, Tang CA, Song JH, Mancuso A, Del Valle JR, Cao J, Xiang Y, Dand CV, Sanchez DJ, Keith B, Hu CA, Simon MC*
J. Clin. Inv. (2018), 128, 1300. Link
38. Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice
Schutt SD, Wu Y, Tang CA, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CA,
Yu XZ*
Blood Adv. (2018), 2, 414. Link
Schutt SD, Wu Y, Tang CA, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CA,
Yu XZ*
Blood Adv. (2018), 2, 414. Link
37. Synthesis and β-sheet propensity of constrained N-amino peptides
Sarnowski MP, Pedretty KP, Giddings N, Woodcock HL, Del Valle JR*
Bioorg. Med. Chem. (2018), 26, 1162. Link
Sarnowski MP, Pedretty KP, Giddings N, Woodcock HL, Del Valle JR*
Bioorg. Med. Chem. (2018), 26, 1162. Link
36. Peptide N-amination supports β-sheet conformation
Sarnowski MP, Kang C, Elbatrawi YM, Wojtas L, Del Valle JR*
Angew. Chem. Int. Ed. (2017), 56, 2083. Link
** Selected as a ‘Hot Paper’ by Angewandte Chemie**
** Faculty of 1000 selection**
Sarnowski MP, Kang C, Elbatrawi YM, Wojtas L, Del Valle JR*
Angew. Chem. Int. Ed. (2017), 56, 2083. Link
** Selected as a ‘Hot Paper’ by Angewandte Chemie**
** Faculty of 1000 selection**
35. Access to enantiopure α-hydrazino acids for N-amino peptide synthesis
Kang C, Sarnowski MP, Elbatrawi YM, Del Valle JR*
J. Org. Chem. (2017), 82, 1833. Link
Kang C, Sarnowski MP, Elbatrawi YM, Del Valle JR*
J. Org. Chem. (2017), 82, 1833. Link
34. Regulated Inositol-Requiring Enzyme 1 dependent mRNA decay sets the threshold for dendritic cell survival
Tavernier S, Osorio F, Vandersarren L, Vetters J, Van-langenakker N, Van Isterdael G, Vergote K, Parthoens F, Van de laar L,
Iwawaki T, Del Valle JR, Hu CA, Janssens S*, Nature Cell Biol. (2017), 19, 698. Link
Tavernier S, Osorio F, Vandersarren L, Vetters J, Van-langenakker N, Van Isterdael G, Vergote K, Parthoens F, Van de laar L,
Iwawaki T, Del Valle JR, Hu CA, Janssens S*, Nature Cell Biol. (2017), 19, 698. Link
33. Heterocyclic extended dipeptide surrogates for β-strand stabilization
Del Valle JR*, In Topics in Heterocyclic Chemistry - Peptidomimetics II; Lubell, W., Ed.; Springer International Publishing, 2017, p25-49. Link
32. Agonist-mediated activation of STING induces apoptosis in malignant cells
Tang CA, Zundell JA, Ranatunga S, Lin C, Nefedova Y, Del Valle JR, Hu CA*, Cancer Res. (2016), 76, 2137. Link
31. β-strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching
Kang C, Sarnowski MP, Ranatunga S, Wojtas L, Metcalf RD, Guida WC, Del Valle JR*, Chem. Comm. (2015), 15, 16259. Link
Tang CA, Zundell JA, Ranatunga S, Lin C, Nefedova Y, Del Valle JR, Hu CA*, Cancer Res. (2016), 76, 2137. Link
31. β-strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching
Kang C, Sarnowski MP, Ranatunga S, Wojtas L, Metcalf RD, Guida WC, Del Valle JR*, Chem. Comm. (2015), 15, 16259. Link
30. Solid-phase synthesis of tetrahydropyridazinedione-constrained peptides
Kang C, Ranatunga S, Sarnowski MP, Del Valle JR*, Org. Lett. (2014), 16, 5434. Link
Kang C, Ranatunga S, Sarnowski MP, Del Valle JR*, Org. Lett. (2014), 16, 5434. Link
29. Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt
Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR*, Bioorg. Med. Chem. Lett. (2014) 24, 4650. Link
Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR*, Bioorg. Med. Chem. Lett. (2014) 24, 4650. Link
28. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity
Ranatunga S, Tang CA, Kang C, Kloppenburg B, Kriss CL, Hu CA, Del Valle JR*, J. Med. Chem. (2014) 57, 4289. Link
** Highlighted in SciBx ‘This Week in Therapeutics’ DOI: 10.1038/scibx.2014.702**
Ranatunga S, Tang CA, Kang C, Kloppenburg B, Kriss CL, Hu CA, Del Valle JR*, J. Med. Chem. (2014) 57, 4289. Link
** Highlighted in SciBx ‘This Week in Therapeutics’ DOI: 10.1038/scibx.2014.702**
27. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival
Tang, CA, Ranatunga S, Kriss, CL, Cubbitt CL, Pinilla-Ibarz JA, Del Valle JR*, Hu CA*, J. Clin. Inv. (2014) 124, 2585. Link
** Highlighted in Cancer Discovery ‘Research Watch’ DOI: 10.1158/2159-8290.CD-RW2014**
** Highlighted in SciBx ‘This Week in Therapeutics’ DOI: 10.1038/scibx.2014.702**
26. Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics
Kang C, Sun Y, Del Valle JR*, Org. Lett. (2012) 14, 6162-5. Link
Kang C, Sun Y, Del Valle JR*, Org. Lett. (2012) 14, 6162-5. Link
25. Total synthesis and structural confirmation of lucentamycin A
Ranatunga S, Tang CA, Hu CA, Del Valle JR*, J. Org. Chem. (2012) 77, 9859-64. Link
Ranatunga S, Tang CA, Hu CA, Del Valle JR*, J. Org. Chem. (2012) 77, 9859-64. Link
24. Structure assignment of lucentamycin E and revision of the olefin geometries of the marine-derived lucentamycins
Cha JW, Park JS, Sim T, N SJ, Kwon HC, Del Valle JR, Fenical W*, J. Nat. Prod. (2012) 75, 1648. Link
23. Synthesis and evaluation of substituted hexahydronaphthalene derivatives as novel inhibitors of the Mcl-1/BimBH3
interaction
Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR*, Bioorg. Med. Chem.
Lett. (2012) 22, 5961-5. Link
Cha JW, Park JS, Sim T, N SJ, Kwon HC, Del Valle JR, Fenical W*, J. Nat. Prod. (2012) 75, 1648. Link
23. Synthesis and evaluation of substituted hexahydronaphthalene derivatives as novel inhibitors of the Mcl-1/BimBH3
interaction
Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR*, Bioorg. Med. Chem.
Lett. (2012) 22, 5961-5. Link
22. Overexpression of TCL1 activates endoplasmic reticulum stress response: A novel mechanism of leukemic progression
in mice
Kriss CL, Pinilla-Ibarz JA, Mallioux A, Powers JJ, Tang CA, Kang C, Zanesi N, Epling-Burnette PK, Sotomayor EM, Croce CM,
Del Valle JR*, Hu, CA*, Blood (2012) 120, 1027-1038. Link
21. An Ester Enolate-Claisen Rearrangement Route to Substituted 4-Alkylideneprolines. Studies toward a Definitive
Structural Revision of Lucentamycin A
Ranatunga S, Kim JS, Pal U, Del Valle JR*, J. Org. Chem. (2011) 76, 8962-76. Link
** Selected for ACS ‘Virtual Issue on Peptide Chemistry’**
in mice
Kriss CL, Pinilla-Ibarz JA, Mallioux A, Powers JJ, Tang CA, Kang C, Zanesi N, Epling-Burnette PK, Sotomayor EM, Croce CM,
Del Valle JR*, Hu, CA*, Blood (2012) 120, 1027-1038. Link
21. An Ester Enolate-Claisen Rearrangement Route to Substituted 4-Alkylideneprolines. Studies toward a Definitive
Structural Revision of Lucentamycin A
Ranatunga S, Kim JS, Pal U, Del Valle JR*, J. Org. Chem. (2011) 76, 8962-76. Link
** Selected for ACS ‘Virtual Issue on Peptide Chemistry’**
20. Synthesis of GSK3β-Mimetic Inhibitors of Akt Featuring a Novel Extended Dipeptide Surrogate
Ranatunga S, Del Valle JR*, Bioorg. Med. Chem. Lett. (2011) 21, 7166-9. Link
Ranatunga S, Del Valle JR*, Bioorg. Med. Chem. Lett. (2011) 21, 7166-9. Link
19. Synthesis of a diversifiable cis-dehydrodecalin scaffold based on meiogynin A
Kim YB, Del Valle JR*, Tetrahedron Lett. (2011) 52, 6396-8. Link
Kim YB, Del Valle JR*, Tetrahedron Lett. (2011) 52, 6396-8. Link
18. Synthesis and conformational analysis of bicyclic extended dipeptide surrogates
Ranatunga S, Liyanage W, Del Valle JR*, J. Org. Chem. (2010) 75, 5113-25. Link
17. Synthesis of Boc-protected bicycloproline
Ranatunga S, Del Valle JR*, Tetrahedron Lett. (2009) 50, 2464-6. Link
Ranatunga S, Del Valle JR*, Tetrahedron Lett. (2009) 50, 2464-6. Link
16. Total synthesis of the putative structure of lucentamycin A
Pal U, Ranatunga S, Ariyarathna Y, Del Valle JR*, Org. Lett. (2009) 11, 5298-301. Link
Pal U, Ranatunga S, Ariyarathna Y, Del Valle JR*, Org. Lett. (2009) 11, 5298-301. Link
15. Synthesis of carbapyochelins via diastereoselective azidation of 5-(ethoxycarbonyl)methylproline derivatives
Liyanage W, Weerasinghe L, Strong RK, Del Valle JR*, J. Org. Chem. (2008) 73, 7420-3. Link
Liyanage W, Weerasinghe L, Strong RK, Del Valle JR*, J. Org. Chem. (2008) 73, 7420-3. Link
FROM GRADUATE AND POSTDOCTORAL WORK:
14. Synthesis of functionalized octahydroindoles related to daphnyphyllum alkaloids.
Dorich S, Del Valle JR, Hanessian S*, Synlett (2014) 25, 799-804. Link
13. Aeruginosins as thrombin inhibitors.
Del Valle JR, Thierren E, Hanessian S*, In Natural Products in Medicinal Chemistry, Vol. 60: Wiley-VCH; 2013. p. 333-56. Link
12. Total synthesis of pactamycin.
Hanessian S*, Vakiti RR, Dorich S, Banerjee S, Lecomte F, Del Valle JR, Zhang J, Deschenes-Simard B, Angew. Chem. Int. Ed.
(2011) 50, 3497-500. Link
11. Total synthesis and structural revision of the presumed aeruginosins 205A and B.
Hanessian S*, Wang X, Ersmark K, Del Valle JR, Klegraf E, Org. Lett. (2009) 11, 4232-5. Link
10. β-Substituted D-leucines and their relevance in the total synthesis of natural and unnatural aeruginosins.
Del Valle JR, Wang X, Ersmark K, Hanessian S*, In Asymmetric Synthesis and Application of alpha-Amino Acids: American
Chemical Society; 2009. p. 443-61. Link
9. Chemistry and biology of the aeruginosin family of serine protease inhibitors.
Ersmark K, Del Valle JR, Hanessian S*, Angew. Chem. Int. Ed. (2008) 47, 1202-23. Link
8. Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin.
Hanessian S*, Ersmark K, Wang X, Del Valle JR, Blomberg N, Xue Y, Bioorg. Med. Chem. Lett. (2007) 17, 3480-5. Link
7. Total synthesis and structural confirmation of chlorodysinosin A.
Hanessian S*, Del Valle JR, Xue Y, Blomberg, N, J. Am. Chem. Soc. (2006) 128, 10491-5. Link
6. Utilizing the intramolecular Fukuyama-Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for
peptidomimetic drug design.
Zapf CW, Del Valle JR, Goodman M*, Bioorg. Med. Chem. Lett. (2005) 15, 4033-6. Link
5. Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric
implications of nucleophilic alkene, alkyne, and allene tethers.
Hanessian S*, Tremblay M, Marzi M, Del Valle JR, J. Org. Chem. (2005) 70, 5070-85. Link
4. An efficient RCM-based synthesis of orthogonally protected meso-DAP and FK565.
Del Valle JR, Goodman M*, J. Org. Chem. (2004) 69, 8946-8. Link
3. Asymmetric hydrogenations for the synthesis of Boc-protected 4-alkylprolinols and prolines.
Del Valle JR, Goodman M*, J. Org. Chem. (2003) 68, 3923-31. Link
2. Stereoselective synthesis of Boc-protected cis and trans-4-trifluoromethylprolines by asymmetric hydrogenation
reactions.
Del Valle JR, Goodman M*, Angew. Chem. Int. Ed. (2002) 41, 1600-2. Link
1. Molecular basis of sweet taste in dipeptide taste ligands.
Goodman M*, Del Valle JR, Amino Y, Benedetti E, Pure Appl. Chem. (2002) 74, 1109-16. Link
14. Synthesis of functionalized octahydroindoles related to daphnyphyllum alkaloids.
Dorich S, Del Valle JR, Hanessian S*, Synlett (2014) 25, 799-804. Link
13. Aeruginosins as thrombin inhibitors.
Del Valle JR, Thierren E, Hanessian S*, In Natural Products in Medicinal Chemistry, Vol. 60: Wiley-VCH; 2013. p. 333-56. Link
12. Total synthesis of pactamycin.
Hanessian S*, Vakiti RR, Dorich S, Banerjee S, Lecomte F, Del Valle JR, Zhang J, Deschenes-Simard B, Angew. Chem. Int. Ed.
(2011) 50, 3497-500. Link
11. Total synthesis and structural revision of the presumed aeruginosins 205A and B.
Hanessian S*, Wang X, Ersmark K, Del Valle JR, Klegraf E, Org. Lett. (2009) 11, 4232-5. Link
10. β-Substituted D-leucines and their relevance in the total synthesis of natural and unnatural aeruginosins.
Del Valle JR, Wang X, Ersmark K, Hanessian S*, In Asymmetric Synthesis and Application of alpha-Amino Acids: American
Chemical Society; 2009. p. 443-61. Link
9. Chemistry and biology of the aeruginosin family of serine protease inhibitors.
Ersmark K, Del Valle JR, Hanessian S*, Angew. Chem. Int. Ed. (2008) 47, 1202-23. Link
8. Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin.
Hanessian S*, Ersmark K, Wang X, Del Valle JR, Blomberg N, Xue Y, Bioorg. Med. Chem. Lett. (2007) 17, 3480-5. Link
7. Total synthesis and structural confirmation of chlorodysinosin A.
Hanessian S*, Del Valle JR, Xue Y, Blomberg, N, J. Am. Chem. Soc. (2006) 128, 10491-5. Link
6. Utilizing the intramolecular Fukuyama-Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for
peptidomimetic drug design.
Zapf CW, Del Valle JR, Goodman M*, Bioorg. Med. Chem. Lett. (2005) 15, 4033-6. Link
5. Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric
implications of nucleophilic alkene, alkyne, and allene tethers.
Hanessian S*, Tremblay M, Marzi M, Del Valle JR, J. Org. Chem. (2005) 70, 5070-85. Link
4. An efficient RCM-based synthesis of orthogonally protected meso-DAP and FK565.
Del Valle JR, Goodman M*, J. Org. Chem. (2004) 69, 8946-8. Link
3. Asymmetric hydrogenations for the synthesis of Boc-protected 4-alkylprolinols and prolines.
Del Valle JR, Goodman M*, J. Org. Chem. (2003) 68, 3923-31. Link
2. Stereoselective synthesis of Boc-protected cis and trans-4-trifluoromethylprolines by asymmetric hydrogenation
reactions.
Del Valle JR, Goodman M*, Angew. Chem. Int. Ed. (2002) 41, 1600-2. Link
1. Molecular basis of sweet taste in dipeptide taste ligands.
Goodman M*, Del Valle JR, Amino Y, Benedetti E, Pure Appl. Chem. (2002) 74, 1109-16. Link